\n

Email: arikd@bgu.ac.il

","url":"?popup=5803debb-7f1e-4071-a601-6b8637f9c487"},{"key":"a71c89ab868c4f839bba360e1b189a8b","fullName":"David Stepensky","subTitle":"Pharmacokinetics, pharmacodynamics, and drug delivery systems ","description":"

David Stepensky

\n

Pharmacokinetics, pharmacodynamics, and drug delivery systems

\n

Our lab investigates the processes that govern drug transport in the body and their pharmacological effects. Each drug has a unique set of biopharmaceutical, pharmacokinetic, and pharmacodynamic properties that vary between individual patients and frequently necessitate dose and treatment adjustments. We analyze the dose-concentration-effect relationships of drugs in laboratory animals and patients and use mathematical/statistical analysis (PK-PD modeling) to quantitatively describe these relationships. An in-depth understanding of the processes of drug transport and pharmacological effects serves as a basis for the design, development, and characterization of drug delivery systems for targeting drugs to their site of action and enhancing their efficacy/safety balance in the individual patients.

\n

Email: davidst@bgu.ac.il

\n

Phone: 054-5349669

\n

Orcid ID: 0000-0001-7206-8352

\n

Personal website: https://fohs.bgu.ac.il/research/profileBrief.aspx?id=VurisurMt

\n

 

","url":"?popup=a71c89ab-868c-4f83-9bba-360e1b189a8b"},{"key":"ff09093d83144ec3b802fb17f4b010a3","fullName":"Stas (Stanislav) Engel","subTitle":"Molecular mechanism of muscular in ALS ","description":"

Stas (Stanislav) Engel

\n

Molecular mechanism of muscular in ALS

\n

The current research in the lab focuses on evaluating the therapeutic potential of a novel SOD1-targeted mAb developed in our lab, using cell and animal ALS models. In addition, we use the new antibody to elucidate the mechanism of SOD1 structural transformation into neurotoxic species.

\n

Email: engels@bgu.ac.il

\n

Personal website: https://engels45.wixsite.com/engelslab

\n

 

","url":"?popup=ff09093d-8314-4ec3-b802-fb17f4b010a3"},{"key":"6d0b85df096b4e4b846fc4bd329d9e56","fullName":"Sigal Fleisher","subTitle":"Neuroinflammation","description":"

Sigal Fleisher

\n

Neuroinflammation

\n

The lab studies the regulation of neuroinflammation, including the effect of neuropeptides on Alzheimer's disease, and the use of medicinal cannabis strains and cannabinoids to regulate neuroinflammation in multiple sclerosis patients.

\n

Email: fleisher@bgu.ac.il

","url":"?popup=6d0b85df-096b-4e4b-846f-c4bd329d9e56"},{"key":"98150fa53bf94306b12bd6bfb31c5f16","fullName":"Yoav Sharoni","subTitle":"The endocrine laboratory for the study of hormones and nutrients ","description":"

Yoav Sharoni

\n

The endocrine laboratory for the study of hormones and nutrients

\n

Our research aims to understand how dietary derived compounds (phytonutrients, mainly carotenoids and polyphenols) can affect human health. We study the effects of phytonutrients on various cellular activities of bone and skin cells, which may reverse the deterioration of these tissues due to exogenous and endogenous factors. We study bone cells under reduced gravity that causes degradation of the bone matrix and osteoporosis. We examine how phytonutrients can reduce the activity of osteoclasts, which degrade the bone, and improve the activity of osteoblasts, which build the bone. In skin cells, we try to prevent the deleterious effects of oxidative stress that can result from exogenous factors, such as UV and smoking or during aging. We examine the role of the combination of phytonutrients and estrogens in reducing oxidative stress and its negative effects by activating antioxidant defense mechanisms and modulating signaling pathways. The studies are conducted with the relevant cells in culture and a 3D bone model.

\n

Email: yoav@bgu.ac.il

","url":"?popup=98150fa5-3bf9-4306-b12b-d6bfb31c5f16"},{"key":"38a2e3626c084497a4ab80b65a476a82","fullName":"Galila Agam ","subTitle":"Translational research of neuropsychiatric disorders","description":"

Galila Agam

\n

Translational research of neuropsychiatric disorders

\n

The research deals with the etiology of neuropsychiatric disorders, bipolar disorder and schizophrenia in particular, and the mechanism of both the benefits and side effects of psychotropic drugs. Within the concept of personalized medicine she and her group strive to uncover positive response predictors of given patients to an optimal drug among the various options.

\n

Email: galila@bgu.ac.il

\n

Phone: +972-52-5706388

\n

Orcid ID: 0000-0001-6845-2554

\n

Personal website: https://cris.bgu.ac.il/en/persons/galila-agam

","url":"?popup=38a2e362-6c08-4497-a4ab-80b65a476a82"},{"key":"5797acfa33b34d1d99ac342b47b06462","fullName":"Danielle Karo-Atar","subTitle":"Immunology, Infectious Diseases, and Stem Cell Biology ","profileImage":"/media/o5xha11v/20230904_018.jpg","description":"

Danielle Karo-Atar

\n

Immunology, Infectious Diseases, and Stem Cell Biology

\n

Our research centers on the immune response to infectious diseases, our focus is enteric pathogen infections—particularly helminth infections. We integrate stem cell biology and immunology to investigate host-pathogen interactions at the intestinal epithelial interface. We use advanced methodologies including 3D organoid cultures, confocal imaging, transcriptomic analyses, and in vivo genetic models to elucidate how helminths influence intestinal immunity with the aim to understand the intestinal response to damage and develop new therapeutic approaches to promote intestinal health.

\n

Email: atardani@bgu.ac.il 

\n

Phone: 08-6477357

\n

Orcid ID: https://orcid.org/0000-0002-0225-8836

\n

Personal website: www.karoatarlab.com

","url":"?popup=5797acfa-33b3-4d1d-99ac-342b47b06462"},{"key":"377e9e06181441ab9e90e4aedc451192","fullName":"Riad Agbaria","subTitle":"Natural Therapeutics","profileImage":"/media/xj0jz4gr/riad_-009.jpg","description":"

Riad Agbaria

\n

Natural Therapeutics

\n

The primary focus of my recent research focuses on natural therapeutics, with particular emphasis on investigating the therapeutic properties of black seed oil (Nigella sativa). My studies explore the potential of this natural compound in treating a range of diseases. Specifically, I have examined its antitumor effects as well as its influence on mental illness, utilizing both in vitro experiments and animal models.

\n

Email: riad@bgu.ac.il

\n

Phone: 08-6477372

","url":"?popup=377e9e06-1814-41ab-9e90-e4aedc451192"},{"key":"8bd0ac1537c149b0b27cd9d315448677","fullName":"Amos Douvdevani","subTitle":"Nephrology ","description":"

Amos Douvdevani

\n

Nephrology

\n

The main research topics in the lab are: 1. Development of a novel peritoneal dialysis fluid based on a conventional fluid with a blocker of peritoneal sodium glucose cotransporter. Peritoneal dialysis is a renal replacement therapy for patients with end-stage renal disease. The aims are to improve ultrafiltration and reduce the undesirable metabolic effects of standard glucose-containing dialysis fluids. The study is mainly based on animal models, some tissue culture experiments, and future clinical studies on patients. 2. Evaluation of the predictive value of circulating cell-free DNA (cfDNA) in various pathological conditions. We have developed a simple, rapid fluorescent assay for measuring blood cfDNA concentrations. cfDNA is a product of cell necrosis, apoptosis, and active secretion. It is an excellent biomarker because it embeds in its value the damage to affected tissues and inflammation. We conduct local and complex multi-center clinical studies; for example, studies on various populations of patients with end-stage kidney disease, labor complications, and newborn and preterm babies.

\n

Email: amosd@bgu.ac.il

","url":"?popup=8bd0ac15-37c1-49b0-b27c-d9d315448677"},{"key":"7ef496ec14e8499394446a7c1e57a98e","fullName":"Elie Beit-Yannai","subTitle":"Exploring extracellular vesicles and their role in the visual system ","description":"

Elie Beit-Yannai

\n

Exploring extracellular vesicles and their role in the visual system

\n

The laboratory is engaged in investigating the role of the biological nanoparticles secreted from most cells known as exosomes. These vesicles carry proteins, genetic information and fats from the secreting cell and can uniquely affect target cells. Using in-vitro research, we isolate and characterize the exosomes, deliberately changing their contents and/or their surface area, and examine their ability to induce biological change in target cells. The focus of the laboratory is glaucoma and knowledge-based collaborations in the field of exosome research on a variety of biological topics and bioengineering.

\n

Email: bye@bgu.ac.il

\n

Phone: 08-6477374

\n

Orcid ID: 0000-0001-9347-822X

","url":"?popup=7ef496ec-14e8-4993-9444-6a7c1e57a98e"},{"key":"340a2803d3ed4cb4b0cfc3bca8448b57","fullName":"Esti Yeger-Lotem","subTitle":"Bioinformatics and systems medicine ","profileImage":"/media/r2sm2i1w/קדאן.jpg","description":"

Esti Yeger-Lotem

\n

​Bioinformatics and systems medicine

\n

The lab works in the fields of computational systems biology and system medicine. Our research is interdisciplinary and focuses on developing algorithms and computational approaches to map the cell types in the human body, understand how the immune systems change with age, and reveal why hereditary diseases manifest clinically in some tissues and not in others. For this purpose, we combine comprehensive data of various types (genomic, transcriptomic, and more) and machine learning. Web tools developed in the lab are used by researchers from around the world.

\n

Email: estiyl@bgu.ac.il

\n

Personal website: https://netbio.bgu.ac.il 

","url":"?popup=340a2803-d3ed-4cb4-b0cf-c3bca8448b57"},{"key":"40cb18f7115c4a5f89476fcdf3a3b803","fullName":"David Ben-Menahem","subTitle":"Molecular endocrinology ","description":"

David Ben-Menahem

\n

Molecular endocrinology

\n

The research focuses on key hormones in human reproduction, mainly the gonadotropins LH, hCG, and FSH, using a humanized Drosophila model developed in collaboration with Dr. Ross Cagan (formerly at Mount Sinai Medical School, New York). Open research projects in the lab include 1. The use of the humanized Drosophila model for exploring the mechanism of gonadotropin receptor action in a calorie-rich diet and insulin resistance. 2. Elucidating potential non-classical gonadotropin activities outside the gonads. 3. Development of a Drosophila platform for an accelerated search of orally bioactive gonadotropin receptor agonists and antagonists.

\n

Email: dbm@bgu.ac.il

","url":"?popup=40cb18f7-115c-4a5f-8947-6fcdf3a3b803"},{"key":"7000fc527c8d48c795270c1e4808ae8d","fullName":"Rachel Levi","subTitle":"Inflammatory Processes ","description":"

Rachel Levi

\n

Inflammatory Processes

\n

The research investigates inflammatory processes with a major role in the development of various diseases. The main focus is on cytosolic phospholipase A2α, which plays a critical role in the development of inflammation. Our research group engineered a specific antisense drug against this enzyme, to efficiently treat inflammation. After successfully studying different mouse-model diseases, we are currently focusing on neurodegenerative diseases, especially Amyotrophic Lateral Sclerosis (ALS) in a mouse model. In addition, we are studying the role of carotenoids and other phyto-ingredients in inhibiting inflammation.

\n

Email: ral@bgu.ac.il

","url":"?popup=7000fc52-7c8d-48c7-9527-0c1e4808ae8d"},{"key":"22999c25be49447190fe89f6e0478728","fullName":"Michael Danilenko","subTitle":"Leukemia research","description":"

Michael Danilenko

\n

Leukemia research

\n

We investigate the molecular mechanisms of anticancer activity and the therapeutic potential of combinations of natural and synthetic compounds in in vitro and in vivo models of leukemia, particularly acute myeloid leukemia (AML). This preclinical research primarily focuses on the antileukemic effects of vitamin D and A derivatives co-administered with clinically approved or experimental electrophilic agents. Our major goal is to identify and characterize the combinations that demonstrate potent synergistic activity at low, non-toxic doses of each compound. AML is one of the most aggressive forms of hematopoietic malignancies, especially affecting older people who are often unfit for standard intensive chemotherapy. Our research may provide the mechanistic basis and prototype therapeutics for novel effective and safe treatment strategies for AML and other cancers. This mild combinatory approach may also be used to prevent the development of AML in individuals with pre-leukemic conditions, such as myelodysplastic syndromes and in those who have been previously treated with DNA-damaging drugs, e.g. cisplatin or etoposide, for solid cancers.

\n

Email: misha@bgu.ac.il

\n

Orcid ID:  https://orcid.org/0000-0001-9466-6169

","url":"?popup=22999c25-be49-4471-90fe-89f6e0478728"}]' staff-members-manual-mode='true'>